Author

S. L. Holmen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. H. Lum· 2 shared M. W. VanBrocklin· 2 shared R. L. Judson-Torres· 2 shared A. H. Grossmann· 1 shared A. H. Shain· 1 shared A. Rogers· 1 shared A. S. McNeal· 1 shared C. M. Stehn· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

D. H. Lum

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer.

Y. Wee, J. Wang, E. C. Wilson, C. P. Rich, A. Rogers, Z. Tong, E. DeGroot, Y. N. V. Gopal, M. A. Davies, H. A. Ekiz, J. K. H. Tay, C. Stubben, K. M. Boucher, J. M. Oviedo, K. Fairfax, , A. H. Grossmann

This study identifies ARF6-dependent endocytic trafficking of the IFN-gamma receptor as a mechanism driving adaptive immune resistance in cancer, linking it to immune checkpoint blockade efficacy.

bioRxiv · Sep 29, 2023Cancer Biology

Genetic silencing of AKT induces melanoma cell death

G. L. Parkman, T. Turapov, D. A. Kircher, W. J. Burnett, C. M. Stehn, K. T. O'Toole, R. Flaherty, R. C. Elmer, K. M. Culver, M. Foth, R. Andtbacka, D. H. Lum, R. L. Judson-Torres, M. W. VanBrocklin, S. L. Holmen, M. McMahon

This study shows that genetic silencing of AKT paralogs in melanoma cells leads to cell death via mTORC signaling disruption, which can be rescued by activated SGK1, suggesting dual targeting of AKT and SGK1 as a potential therapy.

bioRxiv · Aug 15, 2022 · PreprintCancer Biology

BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB.

A. S. McNeal, R. L. Belote, H. Zeng, M. Urquijo, K. Barker, R. Torres, M. Curtin, A. H. Shain, R. H. Andtbacka, S. L. Holmen, D. H. Lum, T. McCalmont, M. W. VanBrocklin, D. Grossman, M. L. Wei, , R. L. Judson-Torres

This study identifies microRNA-mediated suppression of AURKB as a mechanism by which BRAFV600E induces reversible mitotic arrest in human melanocytes, contributing to nevus formation.

bioRxiv · May 21, 2020Cancer Biology