Author

V. Pavet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

O. J. Sansom· 2 shared A. Coates· 1 shared A. D. Campbell· 1 shared A. F. Munro· 1 shared A. H. Y. Chan· 1 shared A. V. Kriegsheim· 1 shared B. Serrels· 1 shared C. A. Ford· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

O. J. Sansom

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Author profile →

2 papers

Recent·Most cited

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

C. A. Ford, D. Koludrovic, P. P. Centeno, M. Foth, E. Tsonou, N. Vlahov, N. Sphyris, K. Gilroy, C. Bull, C. Nixon, B. Serrels, A. F. Munro, J. C. Dawson, N. O. Carragher, V. Pavet, , A. D. Campbell

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

bioRxiv · Feb 26, 2024Cancer Biology

ALDH1A3-acetaldehyde metabolism potentiates transcriptionalheterogeneity in melanoma

Y. Lu, J. Travnickova, M. Badonyi, F. Rambow, A. Coates, Z. Khan, J. Marques, L. Murphy, P. Garcia-Martinez, R. Marais, P. Louphrasitthiphol, A. H. Y. Chan, C. J. Schofield, A. V. Kriegsheim, J. A. Marsh, , E. E. Patton

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

bioRxiv · Oct 28, 2023Cancer Biology