YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells.
A. Claude-Taupin, F. Roccio, M. Garfa-Traore, A. Regnier, M. Burtin, E. Morel, F. Terzi, P. Codogno, N. Dupont
The paper shows YAP/TAZ inhibits autophagy in kidney epithelial cells under fluid flow, mediated by AMPK and SIRT1, and links this to CKD progression.
bioRxiv · Jan 9, 2023Cell Biology