PathologybioRxiv
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
Y. Lei, J. Zhang, C. R. Schiavon…·J. Y.-J. Shyy
This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.
DOI 10.1161/circresaha.121.318902