A. Malhotra

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.

A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.

A continental scale analysis reveals widespread root bimodality

The paper analyzes continental-scale root data and finds widespread root bimodality, with secondary root biomass peaks deeper than 60cm, linked to soil nitrogen content and vegetation type.

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

This study uses real-time finite element analysis to apply adaptive mechanical loading to improve bone healing in a mouse vertebral defect model.

Mechano-regulation of bone adaptation is controlled by the local in vivo environment and logarithmically dependent on loading frequency

This study investigates how bone adapts to mechanical loading by analyzing the relationship between loading frequency and bone volume fraction changes, finding a logarithmic dependency.