M. Ikeda

Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

Temporal inhibition of electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and efficacy to the Omicron variant.

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions

This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

This study shows that proteostasis disruption in human fibroblasts leads to mitochondrial dysfunction and biogenesis, contributing to cellular senescence through ROS accumulation and impaired antioxidant defenses.

Epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells

The paper investigates the epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells, finding changes in histone modifications but not DNA methylation.

Two pathways of p27Kip1 degradation are required for murine lymphoma driven by Myc and EBV latent membrane protein 2A

This study shows blocking both cytoplasmic and nuclear degradation pathways of p27Kip1 delays tumor onset in a murine model of EBV-positive Burkitt lymphoma.