AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

bioRxiv · May 15, 2024Biochemistry

Enhanced translation of leaderless mRNAs under oxidative stress in Escherichia coli

L. E. Leiva, O. Orellana, M. Ibba, A. Katz

The paper shows that oxidative stress in E. coli inhibits canonical translation but enhances leaderless mRNA translation, mediated by (p)ppGpp.

bioRxiv · Jun 29, 2021 · PreprintMicrobiology

Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic Pathogens

P. Kelly, F. Hadi-Nezhad, D. Liu, T. J. Lawrence, R. J. Linington, M. Ibba, D. H. Ardell

This paper identifies parasite-specific tRNA-synthetase interactions as a target for broad-spectrum anti-trypanosomal drugs, validated through natural product inhibitors with no human homolog activity.

bioRxiv · Jul 23, 2019Microbiology

The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid

R. Canals, R. R. Chaudhuri, R. E. Steiner, S. V. Owen, N. Quinones-Olvera, M. A. Gordon, M. Ibba, J. C. D. Hinton

The paper uses transposon insertion sequencing to analyze the fitness landscape of Salmonella Typhimurium ST313 strain D23580, identifying essential genes and plasmid-encoded factors affecting growth and macrophage infection.

bioRxiv · Jul 1, 2019Microbiology