M. Ishida

Traveling wave chemotaxis of neutrophil-like HL-60 cells

This study investigates how neutrophil-like HL-60 cells respond to traveling waves of chemoattractants, finding that cell movement depends on wave speed and involves different signaling pathways at the front and back of the wave.

Enhancer evolution as a driving force for lineage-specific paralog usage in the central nervous system.

The paper investigates how enhancer evolution drives lineage-specific paralog usage in hypophysiotropic GnRH neurons across vertebrates, finding that enhancer loss, not regulatory changes, caused paralog role division.

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

The paper introduces OptoMYPT, an optogenetic tool to relax actomyosin contractility, revealing cortical tension's role in cytokinesis by accelerating furrow ingression.

Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space

The paper maps crawling-cell morphodynamics in a deep learning-based feature space using phase-field modeling and identifies key parameters for migratory morphologies under perturbations.

A Neurodevelopmental Disorder Caused by Mutations in the VPS51 Subunit of the GARP and EARP Complexes

This study identifies compound heterozygous VPS51 mutations in a patient with neurodevelopmental disorder, showing impaired GARP/EARP complex assembly and lysosomal dysfunction.