S. Ishihara

Mechanical convergence in mixed populations of mammalian epithelial cell

This study measures mechanical properties of mixed mammalian epithelial cell monolayers and finds that cell mechanics converge after mixing.

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

Scale space calibrates present and subsequent spatial learning in Barnes maze in mice

This study shows that spatial learning in mice is influenced by the scale of the Barnes maze, with larger scale spaces requiring more computational resources and prior learning in larger scales facilitating subsequent learning in smaller scales.

Attachment/detachment of cortical myosin regulates cell junction exchange during cell rearrangement

The paper shows that myosin-II detachment and attachment regulate junction exchange during cell rearrangement through mechanical and signaling interactions.

Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice

This study examines age-related changes in knee osteoarthritis, pain behaviors, and dorsal root ganglia immune profiles in male and female mice, revealing sex-specific differences in cartilage degeneration and immune cell composition.

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

This study shows that Piezo2 is essential for mechanical pain sensitization in osteoarthritis, as Piezo2-deficient mice are protected from mechanical hypersensitivity in two models.

Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space

The paper maps crawling-cell morphodynamics in a deep learning-based feature space using phase-field modeling and identifies key parameters for migratory morphologies under perturbations.

Macrophages drive the inflammatory phase in experimental osteoarthritis

This study shows macrophages drive inflammation in early experimental osteoarthritis by expanding and altering their gene expression in mouse models.