K. Sano

Involvement of TRPV4 in temperature-dependent perspiration in mice

This study shows TRPV4 is involved in temperature-dependent perspiration in mice through interactions with ANO1, and its expression is higher in normohidrotic AIGA patients.

Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection

This study compares mucosal antibody responses in individuals who received mRNA booster vaccinations or experienced breakthrough infections, finding that breakthrough infections induce stronger saliva sIgA responses than boosters.

Enhancer evolution as a driving force for lineage-specific paralog usage in the central nervous system.

The paper investigates how enhancer evolution drives lineage-specific paralog usage in hypophysiotropic GnRH neurons across vertebrates, finding that enhancer loss, not regulatory changes, caused paralog role division.

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

Evolutionary history of mammalian UDP-glucuronosyltransferase (UGT)1 and UGT2 families: the emergence of UGT2B subfamily in eutherians after the diversification of flowering plants

This study investigates the evolutionary history of mammalian UGT1 and UGT2 gene families, finding that UGT2B genes emerged in eutherians after the diversification of flowering plants and are more prevalent in herbivorous mammals.

A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni

The paper identifies Cubam receptor-mediated endocytosis and cathepsin L proteolysis as mechanisms for maternal nutrient absorption in the pseudoplacenta of a viviparous teleost fish.

The peripheral T cell population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus 2

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

Deep Texture Representations as a Universal Encoder for Pan-cancer Histology

This paper introduces deep texture representations (DTRs) as a universal encoder for cancer histology, enabling accurate prediction of genomic features and cancer types from histological images.

Mother-to-embryo vitellogenin transport in a viviparous teleost Xenotoca eiseni

This study identifies vitellogenin transport from mother to embryo in the viviparous teleost Xenotoca eiseni, showing Vtg presence in ovarian tissues and trophotaenia.

Estrogenic action by tris(2,6-dimethylphenyl) phosphate, an impurity in resorcinol bis flame retardant formulations, impairs the development of female reproductive functions

This study shows that TDMPP, an estrogenic flame retardant impurity, affects female reproductive functions by altering brain development in mice.