Y. Kondo

Cytoplasmic fluidization triggers breaking spore dormancy in fission yeast.

This study identifies a signaling pathway in fission yeast spores that fluidizes the cytoplasm during dormancy breaking, enabling rapid cellular responses to glucose.

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.

This study shows that extracellular sodium concentration directly regulates FGF23 synthesis in osteoblast-like cells and links this regulation to NFAT5 expression, with implications for disease states like hyponatremia.

Harnessing deep learning to analyze cryptic morphological variability of Marchantia polymorpha

This paper uses deep learning to classify sex in Marchantia polymorpha gemmalings, revealing that morphological differences are due to autosomal variation rather than sexual dimorphism.

Live-cell imaging provides direct evidence for a threshold in CDK activity at the G2/M transition

The paper uses live-cell imaging to show CDK activity reaches a threshold at G2/M transition in fission yeast and mammalian cells.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

TET1 attenuates human pluripotency-related heterogeneities and enhances differentiation capabilities

This study shows that adding TET1 to hiPSCs improves their differentiation capabilities and reduces heterogeneity by correcting DNA methylation and gene expression deviations.

The bHLH transcription factor MpHYPNOS regulates gemma dormancy in the liverwort Marchantia polymorpha

This study identifies MpHYPNOS as a key regulator of gemma dormancy in liverworts, showing it represses cell cycle genes and induces ABA biosynthesis through an ABA-independent pathway.

A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane

This study shows that EGFR and Grb2 form a condensate that regulates Ras activation through phosphorylation and dimerization.

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

The paper demonstrates that a simple system of dynein, microtubules, and DNA origami crosslinkers can produce oscillatory movement and repetitive bending without additional regulatory structures.

Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells

The paper uses metabolic flux analysis to show that cancer cells prefer aerobic glycolysis over oxidative phosphorylation due to reduced metabolic heat generation.

Quantitative live-cell fluorescence imaging of GPCR downstream signaling dynamics at the single-cell level.

The paper uses live-cell fluorescence imaging to study GPCR downstream signaling dynamics, revealing heterogeneity among receptors and cells.

Near-infrared imaging in fission yeast by genetically encoded biosynthesis of phycocyanobilin

This paper demonstrates that phycocyanobilin enhances iRFP fluorescence in fission yeast, enabling live-cell near-infrared imaging through engineered biosynthesis systems.

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

The paper introduces OptoMYPT, an optogenetic tool to relax actomyosin contractility, revealing cortical tension's role in cytokinesis by accelerating furrow ingression.

Hierarchical modeling of mechano-chemical dynamics of epithelial sheets across cells and tissue

The paper develops a hierarchical mathematical framework to model mechano-chemical dynamics in epithelial sheets, linking single-cell behavior to tissue-level collective migration through ERK activation waves.

Effect of belt electrode-skeletal muscle electrical stimulation on immobilization-induced muscle fibrosis

This study investigates how belt electrode-skeletal muscle electrical stimulation (B-SES) affects immobilization-induced muscle fibrosis by reducing macrophage accumulation and fibrotic markers in rats.

Leaf form diversification in an heirloom tomato results from alterations in two different HOMEOBOX genes

The paper identifies two HOMEOBOX gene alterations responsible for leaf form diversity in heirloom tomatoes.

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

This study identifies key residues and structural dynamics governing the monomer-dimer equilibrium of hCEACAM1 using biophysical and structural methods.

GSK3 activity is a cell fate switch that balances the ratio of vascular cell type

The study identifies GSK3 activity as a cell fate switch that regulates the ratio of sieve elements to companion cells in the phloem.

Quantitative Detection of Cell Activity by Measuring the Fluctuation of Intracellular Motility

The paper measures cell activity by analyzing intracellular motility fluctuations and finds that damage reduces these fluctuations across cell types.

Origination of the circadian clock system in stem cells regulates cell differentiation in Arabidopsis thaliana.

The paper shows that the circadian clock in Arabidopsis stem cells regulates cell differentiation through BES1-mediated repression of LHY.

Single-cell quantification of the concentration and dissociation constant of endogenous proteins

The paper quantifies endogenous protein concentration and dissociation constant in living cells using CRISPR/Cas9 and FCCS, revealing dynamic changes in protein interactions.

Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death

The paper investigates how p38 cross-inhibits JNK, leading to cell-to-cell variability in JNK activity and contributing to stochastic cell death under stress.