Author

M. J. Garcia-Leon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. Follain· 4 shared J. G. Goetz· 4 shared O. Lefebvre· 4 shared I. Busnelli· 3 shared N. OSMANI· 3 shared A. Larnicol· 2 shared A. PICHOT· 2 shared L. MERCIER· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

G. Follain

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Author profile →

4 papers

Recent·Most cited

Platelets favor the outgrowth of established metastases

M. J. Garcia-Leon, O. Lefebvre, G. Follain, C. Mouriaux, I. Busnelli, A. Larnicol, F. Colin, V. Mittelheisser, M. Peralta, C. Bourdon, R. Samaniego, M. Jandrot-Perrus, P. H. Mangin, J. G. Goetz

This study shows platelets support both initial metastasis and growth of established metastases, with GPVI inhibition reducing metastasis growth without causing bleeding.

bioRxiv · Oct 28, 2022Cancer Biology

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

G. FOLLAIN, N. OSMANI, L. MERCIER, M. J. GARCIA-LEON, I. BUSNELLI, A. PICHOT, N. PAUL, R. CARAPITO, S. BAHRAM, O. LEFEBVRE, J. G. GOETZ

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

bioRxiv · Jul 27, 2020Cancer Biology

Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

N. Osmani, G. Follain, M. J. Garcia-Leon, O. Lefebvre, I. Busnelli, A. Larnicol, S. Harlepp, J. G. GOETZ

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

bioRxiv · Jun 20, 2019Cancer Biology

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

G. Follain, N. Osmani, S. Azevedo, G. Allio, L. Mercier, M. Karreman, G. Solecki, M. J. Garcia-Leon, O. Lefebvre, N. Fekonja, C. Hille, V. Chabannes, G. Dolle, T. Metivet, F. Der Hovsepian, , J. G. Goetz

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

bioRxiv · Jan 10, 2018Cancer Biology