S. Harlepp

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

3D single cell migration driven by temporal correlation between oscillating force dipoles

This study shows that 3D cell migration is driven by synchronized force dipoles at the front and back of the cell, mimicking Purcell's scallop theorem.

Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

Hemodynamic forces can be accurately measured in vivo with optical tweezers

This study introduces a method to accurately measure hemodynamic forces in vivo using optical tweezers and calibrated trap stiffness, validated in zebrafish embryos.