G. Follain

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

Platelets favor the outgrowth of established metastases

This study shows platelets support both initial metastasis and growth of established metastases, with GPVI inhibition reducing metastasis growth without causing bleeding.

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

This paper introduces eSRRF, an enhanced super-resolution imaging method that improves image fidelity and extends to 3D imaging using multi-focus microscopy.

Automated cell tracking using StarDist and TrackMate

This paper presents an automated cell tracking pipeline using StarDist and TrackMate for 2D live-cell imaging, applicable to fluorescent and brightfield images without coding knowledge.

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

Live tracking of inter-organ communication by endogenous exosomes in vivo

This paper develops a zebrafish model to track endogenous exosomes in vivo, revealing their release, uptake, and trophic role in inter-organ communication.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

Hemodynamic forces can be accurately measured in vivo with optical tweezers

This study introduces a method to accurately measure hemodynamic forces in vivo using optical tweezers and calibrated trap stiffness, validated in zebrafish embryos.