N. Osmani

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

Endothelial calcium firing mediates extravasation of metastatic tumor cells.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.

Deciphering circulating tumor cells binding in a microfluidic system thanks to a parameterized mathematical model

The paper develops a mathematical model to study CTC adhesion in a microfluidic system, revealing the impact of fluid velocity and proteins on cell behavior.

Targeting monocytic Occludin impairs monocyte transmigration and HIV neuroinvasion

This study shows that monocytic Occludin promotes monocyte transmigration into the CNS and that targeting it with peptides can block HIV neuroinvasion.

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

An Arf6- And Caveolae-Dependent Pathway Links Hemidesmosome Remodeling And Mechanoresponse

The paper identifies an Arf6- and caveolae-dependent pathway involved in hemidesmosome remodeling and mechanoresponse, showing integrin recycling and Cav1 dynamics under mechanical stress.