J. G. Goetz

The paper develops a mathematical model to study CTC adhesion in a microfluidic system, revealing the impact of fluid velocity and proteins on cell behavior.

This study shows that monocytic Occludin promotes monocyte transmigration into the CNS and that targeting it with peptides can block HIV neuroinvasion.

This study shows that lysosomal positioning in melanoma cells correlates with aggressiveness, promoting invasion and matrix degradation.

This study shows that blood flow enhances the pro-angiogenic effects of tumor-derived extracellular vesicles by altering their intracellular trafficking in endothelial cells.

This study shows platelets support both initial metastasis and growth of established metastases, with GPVI inhibition reducing metastasis growth without causing bleeding.

This study identifies MLKL as a regulator of EV release from GSCs, showing its role in promoting tumour growth and suggesting EV targeting as a therapeutic strategy.

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

This study introduces a method to accurately measure hemodynamic forces in vivo using optical tweezers and calibrated trap stiffness, validated in zebrafish embryos.

The paper identifies an Arf6- and caveolae-dependent pathway involved in hemidesmosome remodeling and mechanoresponse, showing integrin recycling and Cav1 dynamics under mechanical stress.

This study shows that laminin α1 promotes colon tumor growth by facilitating VEGFA-driven angiogenesis through interactions with integrin β1 and CXCR4.