ImmunologybioRxiv
Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression
Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz…·C. G. Drake
This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.
DOI 10.1038/s43018-021-00227-3