C. G. Drake

The paper identifies KLRG1-expressing CD4 T cell subsets linked to tumor progression and immunotherapy response using longitudinal flow cytometry and machine learning.

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.

The paper develops a single-cell framework to prioritize drugs for cholangiocarcinoma by analyzing subpopulations and validating predictions in patient-derived xenografts.

This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.