ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway
T. Cremer, M. L. M. Jongsma, F. Trulsson…·I. Berlin
The paper identifies an ER-embedded UBE2J1/RNF26 ubiquitylation complex that regulates endolysosomal positioning and cargo downregulation through substrate modification and adaptor recruitment.