Author

T. Cremer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

I. Berlin· 2 shared J. Neefjes· 2 shared M. Cremer· 2 shared Y. Markaki· 2 shared A. C. O. Vertegaal· 1 shared A. I. Costa· 1 shared A. Maiser· 1 shared A. Szczurek· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

I. Berlin

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6 papers

Recent·Most cited

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

T. Cremer, H. Hoelen, M. L. van de Weijer, G. Janssen, A. I. Costa, P. van Veelen, R. J. Lebbink, E. Wiertz

This study identifies UBE2G2 as a key enzyme in the ERAD-mediated degradation of proinsulin, leading to the presentation of a proinsulin B-chain autoantigen in T1D.

PLOS ONE · May 24, 2024Peer-reviewedCell Biology

Vimentin intermediate filaments organize organellar architecture in response to ER stress

T. Cremer, L. M. Voortman, D. van Elsland, E. Bos, L. R. Ter Haar, R. I. Koning, I. Berlin, J. Neefjes

This paper identifies a new role for Vimentin intermediate filaments in organizing perinuclear ER and endosomal architecture through interaction with RNF26 during ER stress.

bioRxiv · Mar 24, 2022Cell Biology

True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin

M. Gelleri, S.-Y. Chen, A. Szczurek, B. Hübner, M. Sterr, J. Neumann, O. Kröger, F. Sadlo, J. Imhoff, Y. Markaki, M. J. Hendzel, M. Cremer, T. Cremer, H. Strickfaden, C. Cremer

The paper presents true-to-scale DNA-density maps of human and mouse nuclei, revealing significant accessibility differences between active and inactive compartments.

bioRxiv · Mar 23, 2022Cell Biology

Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair

Y. Horikoshi, H. Shima, W. Kobayashi, J. Sun, V. J. Schmid, H. Ochiai, L. Shi, F. Atsuhiko, Y. Kinugasa, H. Kurumizaka, T. Ikura, Y. Markaki, S.-i. Tate, K. Igarashi, T. Cremer, S. Tashiro

This study shows RAD51 forms distinctive nuclear zones to facilitate homologous recombination by bridging damaged and intact DNA during repair.

bioRxiv · Nov 29, 2021 · PreprintCell Biology

ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway

T. Cremer, M. L. M. Jongsma, F. Trulsson, A. C. O. Vertegaal, J. Neefjes, I. Berlin

The paper identifies an ER-embedded UBE2J1/RNF26 ubiquitylation complex that regulates endolysosomal positioning and cargo downregulation through substrate modification and adaptor recruitment.

bioRxiv · Oct 2, 2020Cell Biology

Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

M. Cremer, K. Brandstetter, A. Maiser, S. S. Rao, V. Schmid, M. Guirao-Ortiz, N. Mitra, S. Mamberti, K. N. Klein, D. M. Gilbert, H. Leonhardt, M. C. Cardoso, E. Lieberman Aiden, H. Harz, T. Cremer

The paper shows cohesin-depleted cells undergo endomitosis and rebuild a multilobulated nucleus with functional compartments despite lacking cohesin.

bioRxiv · Sep 14, 2020Cell Biology