J. Neefjes

Colon cancer and cell transformation by clinical Salmonella strains are associated with bacterial virulence and intracellular fitness

The paper compares NTS strains associated with colon cancer to controls, finding higher transformation efficiency in case strains linked to gene expression and metabolic traits.

Absence of Lipopolysccharide (LPS) expression in Breast Cancer Cells

The paper investigates LPS expression in breast cancer cells and finds no evidence of LPS in cancer cells, but detects it in ducts and immune cells.

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

This study identifies USP16 as an ISG15 cross-reactive deubiquitinase that regulates metabolic pathway-related proteins during type I interferon responses.

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

The paper identifies the ORP9-ORP11 dimer as critical for sphingomyelin synthesis by exchanging phosphatidylserine and phosphatidylinositol-4-phosphate at ER-Golgi contact sites.

Vimentin intermediate filaments organize organellar architecture in response to ER stress

This paper identifies a new role for Vimentin intermediate filaments in organizing perinuclear ER and endosomal architecture through interaction with RNF26 during ER stress.

ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway

The paper identifies an ER-embedded UBE2J1/RNF26 ubiquitylation complex that regulates endolysosomal positioning and cargo downregulation through substrate modification and adaptor recruitment.

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

Invariant chain regulates endosomal fusion and maturation through the SNARE Vti1b

This study identifies Vti1b as a SNARE protein that interacts with invariant chain (Ii) to regulate endosomal fusion and maturation, delaying endosomal maturation for efficient antigen processing.