HR3/RORα-mediated cholesterol sensing regulates TOR signaling
M. Lassen, K. Pardee, L. H. Pedersen, O. Kubrak, T. Koyama, S. Necakov, S. Liu, A. Kuksis, G. Lajoie, A. Edwards, A. A. Teleman, M. R. Larsen, H. M. Krause, M. J. Texada, K. Rewitz
The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.
bioRxiv · Apr 9, 2024Cell Biology