K. Rewitz

Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

The paper shows that cytokine signaling from the Drosophila gut to brain glial cells regulates sleep, with oxidative stress-induced cytokines promoting sleep during intestinal inflammation.

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

A neuronal relay mediates muscle-adipose communication that drives systemic metabolic adaptation to high-sugar diets

The paper identifies a muscle-neuronal-fat tissue axis that modulates insulin secretion and adipocyte sensitivity to high-sugar diets, preventing hyperglycemia.

A gut-derived hormone switches dietary preference after mating in Drosophila

This study identifies a gut hormone in Drosophila that shifts dietary preference to protein-rich food after mating to support reproduction.

Insulin signaling couples growth and early maturation to cholesterol intake

This study shows that dietary cholesterol promotes growth and early maturation in Drosophila by enhancing insulin-like peptide expression through glial and fat-tissue relays.

The gut hormone Allatostatin C regulates food intake and metabolic homeostasis under nutrient stress

A nutrient-responsive hormonal circuit controls energy and water homeostasis in Drosophila

This study identifies a hormonal circuit in Drosophila that regulates energy and water homeostasis by modulating nutrient absorption, intestinal motility, and metabolic processes.

Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control

This study identifies LZTR1 (night owl) and its interaction with Nf1 in regulating GABAergic sleep control, linking them to schizophrenia and 22q11.2 deletion syndrome.