RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer
Z. Li, J. Sun, N. Rahman, B. Yan, S. Utturkar, N. A. Lanman, M. Kazemian, C. Caron de Fromentel, M. Levrero, O. Andrisani
This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.
bioRxiv · Mar 31, 2022 · PreprintCancer Biology