BiochemistrybioRxiv
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
M. M. Keenen, D. Brown, L. D. Brennan…·S. Redding
This study shows HP1 proteins form phase-separated DNA condensates that are mechanically stable but can be dissolved by HP1β, with differences in DNA compaction linked to their disordered regions.
DOI 10.7554/elife.64563