Author

S. Redding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Diehl· 1 shared B. A. Gibson· 1 shared B. Huang· 1 shared C. R. Carlson· 1 shared C. Sultan· 1 shared D. Brown· 1 shared D. Pendlebury· 1 shared E. C. Greene· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Diehl

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

L. Moritz, S. Schon, M. Rabbani, Y. Sheng, D. Pendlebury, R. Agrawal, C. Sultan, K. Jorgensen, X. Zheng, A. Diehl, K. Ragunathan, Y.-C. Hu, J. Nandakumar, J. Li, K. Orwig, , S. Hammoud

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

bioRxiv · Sep 16, 2021 · PreprintBiochemistry

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

M. M. Keenen, D. Brown, L. D. Brennan, R. Renger, H. Khoo, C. R. Carlson, B. Huang, S. W. Grill, G. J. Narlikar, S. Redding

This study shows HP1 proteins form phase-separated DNA condensates that are mechanically stable but can be dissolved by HP1β, with differences in DNA compaction linked to their disordered regions.

bioRxiv · Oct 30, 2020Biochemistry

Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation

B. A. Gibson, L. K. Doolittle, L. E. Jensen, N. Gamarra, S. Redding, M. K. Rosen

This study shows that chromatin undergoes liquid-liquid phase separation under physiological conditions, driven by histone tail interactions and modulated by acetylation and H1, leading to genome compaction and organization.

bioRxiv · Jan 18, 2019Biophysics

Sequential Eviction Of Crowded Nucleoprotein Complexes By The RecBCD Molecular Motor

T. Terakawa, S. Redding, T. D. Silverstein, E. C. Greene

This study investigates how the RecBCD motor protein navigates crowded DNA by evicting bound proteins through sequential pushing, revealing a mechanism distinct from its behavior on naked DNA.

bioRxiv · May 25, 2017Biophysics