M. MacFarlane

The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL

This paper identifies small molecule inhibitors of cFLIP that enhance TRAIL-induced apoptosis in breast cancer cells and improves their potency through structure-activity relationship studies.

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

This study shows that antipsychotics aripiprazole, brexpiprazole, and cariprazine inhibit mitochondrial respiratory complex I, causing toxicity and movement disorders.

Metabolic reprogramming provides a novel approach to overcome resistance to BH3-mimetics in Malignant Pleural Mesothelioma

This study identifies metabolic reprogramming as a strategy to overcome resistance to BH3-mimetics in MPM by combining glycolytic inhibition with MCL-1 and BCL-2/BCL-XL targeting.

TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis

This study identifies TAp73's role in regulating mitochondrial dynamics and multiciliated cell homeostasis through the OPA1 axis, linking it to COPD pathogenesis.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

This study shows that cleavage of cFLIP by Caspase-8 limits cell death during viral infection and tissue injury, promoting tissue repair.

Characterisation of FADD interactome reveals novel insights into FADD recruitment and signalling at the Death Inducing Signalling Complex (DISC)

This study identifies novel FADD interactors that modulate FADD recruitment to the DISC and downstream apoptotic signaling.

Asbestos accelerates disease onset in a genetic model of Malignant Pleural Mesothelioma

This study shows asbestos accelerates mesothelioma onset and increases tumor burden in a genetic mouse model, with increased macrophage infiltration, but macrophage suppression did not improve survival.