Stiffness Regulates Intestinal Stem Cell Fate
S. He, L. Peng, W. Kang, P. Cheung, T. Xu, M. Mana, C. Y. Park, H. Wang, S. Imada, J. O. Russell, J. Wang, R. Wang, Z. Zhou, K. Chetal, E. Stas, , N. Saeidi
This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.
bioRxiv · Mar 15, 2021Cell Biology