L. Peng

Oncogene inactivation-induced senescence facilitates tumor relapse

This study shows that oncogene inactivation-induced senescence both limits tumor growth and promotes relapse by creating a pro-recurrence microenvironment.

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis

This study identifies DNM1 as a master regulator of EMT in ovarian cancer, showing it sustains the mesenchymal state through N-cadherin endocytic recycling and promotes metastasis.

A long non-coding RNA LINC00094 regulates the transcriptional expression of lipid metabolism-related genes as a new member of core regulatory circuitry in esophageal squamous cell carcinoma

This paper identifies LINC00094 as a long non-coding RNA that forms a core regulatory circuitry with TCF3 and KLF5 to regulate lipid metabolism-related genes in esophageal squamous cell carcinoma.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

Phylogenomics resolves a 100-year-old debate regarding the evolutionary history of caddisflies (Insecta: Trichoptera)

This study resolves a century-old debate on caddisfly phylogeny by analyzing genome data from 111 species, clarifying the evolutionary relationships of 'cocoon-makers' and estimating divergence times.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

BCL6 is a context-dependent mediator of the glioblastoma response to irradiation therapy

This study shows that BCL6 in glioblastoma changes its function from repressing DNA damage response to promoting stress response after irradiation, depending on cellular context.

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

Rice OsHAK18 mediates shoot-to-root circulation of potassium and sodium and source-to-sink transport of soluble sugar

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

Growth of Mesenchymal Stem Cells at the Surface of Silicone, Mineral and Plant-Based Oils

This study investigates the assembly of poly(L-lysine) at non-fluorinated oil interfaces and its effect on mesenchymal stem cell adhesion and proliferation.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Simultaneous and sequential multi-species coronavirus vaccination

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces

This study shows how polymer nanosheet architecture affects interfacial toughness, influencing mesenchymal stem cell expansion at liquid interfaces.

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

A broad and potent neutralization epitope in SARS-related coronaviruses

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

Systems immune profiling of variant-specific vaccination against SARS-CoV-2

This study evaluates variant-specific LNP-mRNA vaccines against SARS-CoV-2, showing differential neutralization and immune responses in animal models.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.