M. Matzinger

Challenging the Astral mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity.

This paper introduces a high-throughput single-cell proteomics workflow achieving 5300 protein groups per cell with high accuracy, enabling the study of cellular heterogeneity and lineage differentiation.

A method for deep and quantitative protein profiling of urine sediment, soluble and exosome fractions for biomarker research

This paper introduces a method for deep quantitative proteomics profiling of urine sediment, soluble, and exosome fractions to identify potential biomarkers for kidney disease.

A high-sensitivity low-nanoflow LC-MS configuration for high-throughput sample-limited proteomics

This paper introduces a high-sensitivity LC-MS setup for sample-limited proteomics, achieving 100 runs/day with 70% MS utilization and identifying ~3,000 protein groups from 250 pg of HeLa protein digest.

Robust and easy-to-use one pot workflow for label free single cell proteomics

This paper introduces a one-pot workflow for label-free single-cell proteomics, achieving high sensitivity and reproducibility with a dynamic range of four orders of magnitude.

Wide Window Acquisition and AI-based data analysis to reach deep proteome coverage for a wide sample range, including single cell proteomic inputs

The paper introduces a workflow combining micro pillar array columns, wide window acquisition, and AI-based search engine to enhance proteome coverage and throughput, particularly for single-cell samples.

Deep proteome profiling with reduced carry over using superficially porous microfabricated nanoLC columns

This paper evaluates prototype nanoLC columns for improved proteome profiling, finding increased protein group and peptide identification with reduced carry over and methionine oxidation.

A molecular network of conserved factors keeps ribosomes dormant in the egg

The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.

Fast and highly efficient affinity enrichment of Azide-A-DSBSO cross-linked peptides.

The paper introduces a fast and efficient method to enrich azide-tagged cross-linked peptides, significantly increasing detectable cross-links and sensitivity.