T.-Y. Lin

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Selective activation of intracellular β1AR using a spatially restricted antagonist

This paper develops spatially restricted antagonists to selectively inhibit β1AR signaling at the plasma membrane versus intracellular compartments, revealing compartment-specific effects on downstream signaling.

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

The paper identifies giant genes in predatory bacteria, showing they are associated with prey adhesion and cell wall degradation.

Epinephrine inhibits PI3K alpha via the Hippo kinases.

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

Cardiac contraction and relaxation are regulated by beta 1 adrenergic receptor generated cAMP pools at distinct membrane locations

The paper shows that beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations regulate cardiac contraction and relaxation through different PKA targets.

Anti-spike antibody response to natural infection with SARS-CoV-2 and its activity against emerging variants

This study examines spike-specific antibody responses in SARS-CoV-2 natural infections, showing waning immunity over 11 months and reduced activity against emerging variants like Beta and Omicron.

A molecular network of conserved factors keeps ribosomes dormant in the egg

The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.

Do forest over- and understory respond to the same environmental variables when viewed at the taxonomic and trait level?

This study compares how climate and soil variables influence species and trait patterns in forest overstory and understory vegetation along an elevation gradient in Taiwan.

Comparing trait syndromes between Taiwanese subtropical terrestrial and epiphytic ferns at the species and community level

This study compares trait syndromes between Taiwanese subtropical terrestrial and epiphytic ferns at species and community levels, finding differences in trait values and environmental responses.

The OCT2 Transporter Regulates Dopamine D1 Receptor Signaling at the GolgiApparatus

This study shows that dopamine D1 receptor signaling occurs at the Golgi apparatus via OCT2-mediated activation, revealing a new mechanism for subcellular GPCR function.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

Bacterial swarming reduces Proteus mirabilis and Vibrio parahaemolyticus cell stiffness and increases β-lactam susceptibility