R. Zheng

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

This study develops electrochemical DNA-based sensors to measure cell-generated adhesion forces with high sensitivity and portability.

This study isolates and characterizes a novel deep-sea sulfate-reducing bacterium, revealing its sulfur metabolism and potential coupling with methane oxidation in deep-sea environments.

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

This paper introduces a high-sensitivity LC-MS setup for sample-limited proteomics, achieving 100 runs/day with 70% MS utilization and identifying ~3,000 protein groups from 250 pg of HeLa protein digest.

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

This study introduces a genetically encoded RNA tag to program RNA condensate formation and modulate RNA localization and function in living cells.

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

This study identifies PIP2 as an inhibitor of the PAC channel, revealing its binding site and mechanism through structural and electrophysiological analyses.

This paper introduces genetically encoded RNA-based BRET sensors for real-time target detection in living cells, using a luciferase donor and RNA-based acceptor.

The paper shows polysaccharides trigger deep-sea Lentisphaerae to release chronic bacteriophages that reprogram host polysaccharide metabolism through auxiliary metabolic genes.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

The paper isolates deep-sea PVC bacteria and identifies eukaryotic-like features, suggesting membrane fusion drives eukaryogenesis.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study shows that Withaferin A promotes white adipose browning and prevents obesity by activating the Prdm16-FATP1 pathway via the sympathetic nervous system.

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

This paper describes the isolation and characterization of a novel deep-sea cold seep bacterium, Maribellus comscasis sp. nov., and highlights its genomic and phenotypic features distinguishing it from related species.

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

This paper isolates and characterizes a novel sulfate-reducing bacterium from a deep-sea cold seep, showing its ability to resist and remove heavy metals through sulfur cycling.

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

The paper shows Bacteroidetes are key to deep-sea carbon and nutrient cycling by degrading diverse glycans through metagenomics, isolation, and transcriptomic/metabolomic analyses.

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.