Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.
B. Higgins, I. Simitsidellis, X. Zheng, F. Collins, N. Homer, S. Denham, J. Simpson, M. Millar, L. Boswell, H. Y. Lee, Y. G. Kim, K. H. Park, L. C. Park, P. J. Sweeney, G. Feraille, , D. J. Mole
This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.
bioRxiv · May 13, 2024 · PreprintPathology