An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts
J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Sun, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W.-H. Tham, F. J. Rossello, G. Nie, X. Liu, , J. M. Polo
This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.
bioRxiv · Oct 27, 2021 · PreprintCell Biology