Author

M. Paiardini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Pino· 3 shared A. A. Upadhyay· 2 shared A. K. Boddapati· 2 shared E. G. Viox· 2 shared G. K. Tharp· 2 shared J. D. Estes· 2 shared J. L. Harper· 2 shared K. Busman-Sahay· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

M. Pino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

T. N. Hoang, E. G. Viox, A. A. Upadhyay, Z. Strongin, G. K. Tharp, M. Pino, R. Nchioua, M. Hirschenberger, M. Gagne, K. Nguyen, J. L. Harper, S. Marciano, A. K. Boddapati, K. L. Pellegrini, J. Tisoncik-Go, , M. Paiardini

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

bioRxiv · Oct 21, 2022Immunology

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

A. A. Upadhyay, T. N. Hoang, M. Pino, A. K. Boddapati, E. G. Viox, M. Y. H. Lee, J. Corry, Z. Strongin, D. A. Cowan, E. N. Beagle, T. R. Horton, S. Hamilton, H. Aoued, J. L. Harper, K. Nguyen, , S. E. Bosinger

This study identifies two macrophage populations driving inflammation in the lower airway during SARS-CoV-2 infection in rhesus macaques and shows baricitinib effectively reduces their influx and cytokine production.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses

D. Perez-Zsolt, J. Munoz Basagoiti, J. Rodo, M. Elousa, D. Raich Regue, C. Risco, M. Sachse, M. Pino, S. Gumber, M. Paiardini, J. Chojnacki, I. Erkizia, X. Muniz, E. Ballana, E. Riveira Munoz, , N. Izquierdo-Useros

This study shows Siglec-1 on APCs mediates SARS-CoV-2 trans-infection and triggers proinflammatory responses, suggesting it as a potential therapeutic target.

bioRxiv · May 11, 2021 · PreprintMicrobiology

IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

S. Pereira Ribeiro, M. Aid, F. P. Dupuy, C. Ngai Chan, J. Hultquist, C. Deleage, E. Moysi, D. A. Kulpa, L. Li, X. Xu, B. Tamilselvan, J. A. Tomalka, M. Nekorchuk, K. Busman-Sahay, R. Bordi, , R.-P. Sekaly

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

bioRxiv · Feb 26, 2021 · PreprintImmunology