Author

M. Sachse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Clotet· 3 shared C. Risco· 3 shared D. Perez-Zsolt· 3 shared J. Segales· 3 shared J. Vergara-Alert· 3 shared N. Izquierdo-Useros· 3 shared D. Raich-Regue· 2 shared J. Blanco· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. Clotet

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

S. Schmidt, S. Mondino, L. Gomez-Valero, P. Escoll, D. P. Mascarenhas, A. Goncalves, C. Rusniok, M. Sachse, M. Moya-Nilges, T. Fontaine, D. S. Zamboni, C. Buchrieser

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

bioRxiv · Nov 22, 2023 · PreprintMicrobiology

Beta-Cyclodextrins as affordable antivirals to treat coronavirus infection

D. Raich-Regue, R. Tenorio, I. Fernandez-de-Castro, D. Perez-Zsolt, J. Munoz-Basagoiti, M. Sachse, S. Fernandez-Sanchez, M. Gallemi, P. Ortega-Gonzalez, A. Fernandez-Oliva, J. Gabaldon, E. Nunez-Delicado, J. Casas, F. Tarres, J. Vergara-Alert, , C. Risco

The paper identifies beta-cyclodextrins as effective and affordable antivirals against SARS-CoV-2 and other coronaviruses through molecular modeling and in vitro testing.

bioRxiv · Nov 16, 2022Microbiology

Pharmacological inhibition of titan-like cells formation suggests that accumulation of endogenous free radicals that correlate with mitochondrial changes are required to induce this transition in Cryptococcus neoformans

I. Garcia-Barbazan, R. Garcia-Rodas, M. Sachse, D. Luque, D. Megias, O. Zaragoza

This paper identifies compounds that inhibit titan-like cell formation in Cryptococcus neoformans, suggesting that endogenous ROS and mitochondrial changes are critical for this process.

bioRxiv · Apr 6, 2022 · PreprintMicrobiology

Unraveling the antiviral activity of plitidepsin by subcellular and morphological analysis

M. Sachse, R. Tenorio, I. Fernandez de Castro, J. Munoz-Basagoiti, D. Perez-Zsolt, D. Raich-Regue, J. Rodo, A. Losada, P. Aviles, C. Cuevas, R. Paredes, J. Segales, B. Clotet, J. Vergara-Alert, N. Izquierdo-Useros, C. Risco

This study uses electron microscopy to show plitidepsin blocks SARS-CoV-2 replication organelles and virus morphogenesis.

bioRxiv · Dec 16, 2021Microbiology

A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2

Y. Wu, N. Mahtal, L. Swistak, S. Sagadiev, M. Acharya, C. Demeret, S. Van der Werf, F. Guivel-Benhassine, O. Schwartz, S. Petracchini, A. Mettouchi, E. Paillares, L. Caramelle, P. Couvineau, R. Thai, , E. Lemichez

bioRxiv · Aug 13, 2021Microbiology

Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses

D. Perez-Zsolt, J. Munoz Basagoiti, J. Rodo, M. Elousa, D. Raich Regue, C. Risco, M. Sachse, M. Pino, S. Gumber, M. Paiardini, J. Chojnacki, I. Erkizia, X. Muniz, E. Ballana, E. Riveira Munoz, , N. Izquierdo-Useros

This study shows Siglec-1 on APCs mediates SARS-CoV-2 trans-infection and triggers proinflammatory responses, suggesting it as a potential therapeutic target.

bioRxiv · May 11, 2021 · PreprintMicrobiology

Bacterial FtsZ induces mitochondrial fission in human cells

A. Spier, M. Sachse, N. T. Tham, M. Matondo, P. Cossart, F. Stavru

The paper shows that bacterial FtsZ can induce mitochondrial fission in human cells by localizing to fission sites and increasing fission levels.

bioRxiv · Jan 24, 2020 · PreprintCell Biology