Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2
X. An, M. P. Martinez, A. Rezvan, M. Fathi, S. Singh, S. Biswas, M. Pourpak, C. Yee, X. Liu, N. Varadarajan
This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.
bioRxiv · Jul 23, 2020Immunology