A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion
J. P. Mann, X. Duan, A. Alvarez-Guaita, A. Haider, I. Luijten, M. Page, S. Patel, F. Scurria, M. Protasoni, L. C. Tabara, S. Virtue, S. I. O'Rahilly, M. Armstrong, J. Prudent, R. K. Semple, D. B. Savage
This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.
bioRxiv · Sep 20, 2022Cell Biology