M. Armstrong

Upregulation of a nonsense mediated decay (NMD) insensitive CFTR mRNA isoform has therapeutic potential for the treatment of 3 Prime CFTR PTC variants

The paper shows that upregulating an NMD-insensitive CFTR mRNA isoform with ASOs and ETI can restore partial Cl- transport function in cells with 3' PTC mutations.

Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection.

The paper identifies novel Tr1 cell populations in the lungs of mice during recovery from acute influenza A virus infection, showing their suppressive role and distinct functional dependencies.

BatCount: A software program to count moving animals

BatCount is a software program that automatically counts bats in flight, offering an efficient and reliable tool for population monitoring with potential for broader application to other moving organisms.

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

Fast and scalable lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication in vitro

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

This study shows EPA prevents hyperinsulinemia and hyperglycemia via RvE1, which acts through ERV1/ChemR23, and highlights host genetic variation in metabolic responses.

RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes

This paper introduces RLP/KSeq, a method to rapidly map receptor-like protein (RLP) and receptor-like kinase (RLK) genes in plants, demonstrating its application in identifying PRRs in Solanum species.

The mitotic crosslinking protein PRC1 acts as a mechanical dashpot to resist microtubule sliding

The paper measures the mechanical properties of PRC1, showing it generates velocity-dependent frictional forces that resist microtubule sliding, acting like a mechanical dashpot.

Micro-scale fluid behavior during cryo-EM sample blotting

This paper investigates micro-scale fluid dynamics during cryo-EM sample blotting and identifies issues with uniformity in ice thickness resulting from filter paper interactions.