Author

A. Haider

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

A. Alvarez-Guaita· 3 shared D. B. Savage· 3 shared S. Patel· 3 shared F. Scurria· 2 shared J. P. Mann· 2 shared J. Prudent· 2 shared R. K. Semple· 2 shared S. O'Rahilly· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

A. Alvarez-Guaita

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Loss of Mfn1 but not Mfn2 enhances adipogenesis

J. P. Mann, L. Tabara, A. Alvarez-Guaita, L. Dong, A. Haider, K. Lim, P. Tandon, J. E. Minchin, S. O'Rahilly, S. Patel, D. J. Fazakerley, J. Prudent, R. K. Semple, D. B. Savage

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

J. P. Mann, X. Duan, A. Alvarez-Guaita, A. Haider, I. Luijten, M. Page, S. Patel, F. Scurria, M. Protasoni, L. C. Tabara, S. Virtue, S. I. O'Rahilly, M. Armstrong, J. Prudent, R. K. Semple, D. B. Savage

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

bioRxiv · Sep 20, 2022Cell Biology

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

S. Patel, A. Haider, A. Alvarez-Guaita, G. Bidault, J. S. El-Sayed Moustafa, E. Guiu-Jurado, J. A. Tadross, J. Warner, J. Harrison, S. Virtue, F. Scurria, I. Zvetkova, M. Blüher, K. S. Small, S. O'Rahilly, D. B. Savage

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.

bioRxiv · Jun 8, 2022 · PreprintPhysiology

Rest/Stress Myocardial Perfusion Imaging by Positron Emission Tomography with 18F-Flurpiridaz: A Feasibility Study in Mice

S. Bengs, G. I. Warnock, A. Portmann, N. Mikail, A. Rossi, H. Ahmed, D. Etter, L. Gisler, C. Jie, A. Meisel, C. Keller, R. Schibli, L. Mu, R. R. Buechel, P. A. Kaufmann, , A. Haider

This study evaluates the feasibility of rest/stress PET-MPI with 18F-flurpiridaz in mice, finding that myocardial uptake correlates with perfusion parameters and enables CFR estimation.

bioRxiv · Sep 5, 2021Physiology

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

A. Haider, Z. Xiao, X. Xia, J. Chen, R. S. Van, S. Kuang, C. Zhao, J. Rong, T. Shao, P. Ramesh, A. Aravind, Y. Shao, C. Ran, L. Young, S. H. Liang

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

bioRxiv · Feb 9, 2021Pharmacology & Toxicology