Author

J. P. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Alvarez-Guaita· 2 shared A. Duret· 2 shared A. Haider· 2 shared A. Li· 2 shared C. Hjalmarsson· 2 shared C.-G. Mitrofan· 2 shared D. B. Savage· 2 shared D. de Gracia Hahn· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Alvarez-Guaita

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Author profile →

4 papers

Recent·Most cited

Loss of Mfn1 but not Mfn2 enhances adipogenesis

J. P. Mann, L. Tabara, A. Alvarez-Guaita, L. Dong, A. Haider, K. Lim, P. Tandon, J. E. Minchin, S. O'Rahilly, S. Patel, D. J. Fazakerley, J. Prudent, R. K. Semple, D. B. Savage

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

J. P. Mann, X. Duan, A. Alvarez-Guaita, A. Haider, I. Luijten, M. Page, S. Patel, F. Scurria, M. Protasoni, L. C. Tabara, S. Virtue, S. I. O'Rahilly, M. Armstrong, J. Prudent, R. K. Semple, D. B. Savage

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

bioRxiv · Sep 20, 2022Cell Biology

A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver disease

Y. R. Im, H. Hunter, D. de Gracia Hahn, A. Duret, Q. Cheah, J. Dong, M. Fairey, C. Hjalmarsson, A. Li, H. K. Lim, L. McKeown, C.-G. Mitrofan, R. Rao, M. Utukuri, I. A. Rowe, J. P. Mann

This study analyzes 3,920 rodent models of NAFLD, finding adipose dysfunction and innate immune perturbation are key factors, and high-fat, high-fructose diets best mimic human NAFLD.

bioRxiv · Dec 15, 2020 · PreprintPhysiology

What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression.

H. Hunter, D. de Gracia Hahn, A. Duret, Y. R. Im, Q. Cheah, J. Dong, M. Fairey, C. Hjalmarsson, A. Li, H. K. Lim, L. McKeown, C.-G. Mitrofan, R. Rao, M. Utukuri, I. A. Rowe, J. P. Mann

This paper meta-analyzes rodent studies on NAFLD treatments, finding limited efficacy and high bias, suggesting challenges in translating animal results to human therapies.

bioRxiv · Dec 31, 2019 · PreprintPhysiology