X. Duan

Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

ARHGAP32 as a novel RhoGAP interacting with desmoplakin is required for desmosomal organization and assembly

This study identifies ARHGAP32 as a RhoGAP interacting with desmoplakin, essential for desmosomal organization and epithelial cell sheet integrity by regulating actomyosin contractility.

Polygonum Cillinerve polysaccharide inhibits Transmissible gastroenteritis virus by regulating microRNA-181

This study shows that Polygonum Cillinerve polysaccharide inhibits TGEV infection by modulating miRNA-181 and reducing apoptosis in PK15 cells.

In-vitro digestion models to examine the effects of Plant-Based Meat substitutes on Gut Microbial Metabolites

This study compares the effects of beef, plant-based, and homemade meat substitutes on gut microbial metabolites using in vitro digestion models and metabolomics.

The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

This paper introduces a new 3-D ultrasound imaging technique called FASTER that improves volume rate and usability compared to conventional methods.

How do Vampires Suck Blood?

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

Life-course social disparities in body mass index trajectories across adulthood: cohort study evidence from China Health and Nutrition Survey

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

IL-22/IL-22RA1 promotes human Tenon's capsule fibroblasts proliferation and regulates fibrosis through STAT3 signaling pathway

The paper shows IL-22/IL-22RA1 promotes fibroblast proliferation and fibrosis via STAT3 signaling in glaucoma patients.

Validated Preclinical Murine Model for Therapeutic Testing against Multidrug Resistant Pseudomonas aeruginosa

This paper refines a murine model of Pseudomonas aeruginosa infection to predict antimicrobial efficacy against multidrug-resistant strains.

Structural insights into the mechanism of nucleotide regulation of pancreatic KATP channel

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

Nosocomial Pseudomonas aeruginosaregulates alginate biosynthesis and Type VI secretion system during adaptive and convergent evolution for coinfection in critically ill COVID-19 patients

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

This study identifies TRARG1 as a GSK3 substrate that regulates GLUT4 trafficking and insulin sensitivity through phosphorylation events.

Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

Cep57 and Cep57l1 cooperate to recruit the Cep63-Cep152 complex for centriole biogenesis

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

Extreme tolerance of Paramecium to acute injury induced by γ rays

This study investigates Paramecium's extreme tolerance to γ rays, finding its LD50 is 3000 Gy, 60 times higher than humans, and identifies two upregulated genes potentially involved in DNA protection.

Genomic insights into evolutionary journey of the porcine endogenous retroviruses

The paper uses genomic mining to uncover the evolutionary history of porcine endogenous retroviruses (PERVs), revealing their origins and cross-species transmission events.