EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti
This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.
bioRxiv · Jun 21, 2022Cancer Biology