Author

W. Luan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

S. W. Lowe· 4 shared Y.-J. Ho· 3 shared A. Wuest· 2 shared D. Alonso-Curbelo· 2 shared D. Pe'er· 2 shared F. M. Barriga· 2 shared I. Masilionis· 2 shared J. Simon· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

S. W. Lowe

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Author profile →

5 papers

Recent·Most cited

Metastatic site influences driver gene function in pancreatic cancer

K. M. Tsanov, F. M. Barriga, Y.-J. Ho, D. Alonso-Curbelo, G. Livshits, R. P. Koche, T. Baslan, J. Simon, S. Tian, A. N. Wuest, W. Luan, J. E. Wilkinson, I. Masilionis, N. Dimitrova, C. A. Iacobuzio-Donahue, , S. W. Lowe

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

bioRxiv · Mar 17, 2024 · PreprintCancer Biology

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

A. Katti, M. Foronda, J. Zimmermann, M. P. Zafra, S. Goswami, E. E. Gardner, B. J. Diaz, J. M. Simon, A. Wuest, W. Luan, M. T. C. Fernandez, A. P. Kadina, J. A. Walker, K. Holden, F. J. Sanchez-Rivera, , L. E. Dow

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

bioRxiv · Jul 26, 2022Cancer Biology

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

bioRxiv · Jun 21, 2022Cancer Biology

Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

E. Mahootchi, A. Raasakka, W. Luan, G. Muruganandam, R. Loris, J. Haavik, P. Kursula

The paper determines the crystal structure of mouse CSAD, identifies substrate specificity determinants, and shows open/close motions in solution.

bioRxiv · Sep 25, 2020Biochemistry