Author

K. Simin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

L. J. Zhu· 3 shared J. Li· 2 shared K. C. Murphy· 2 shared K. D. DeMarco· 2 shared M. Ruscetti· 2 shared Y. Lopez-Diaz· 2 shared Y.-j. Ho· 2 shared A. Ali· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

L. J. Zhu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

K. C. Murphy, K. D. DeMarco, L. Zhou, Y. Lopez-Diaz, Y.-j. Ho, J. Li, S. Bai, K. Simin, L. J. Zhu, A. M. Mercurio, M. Ruscetti

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

bioRxiv · Jul 24, 2024Cancer Biology

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

A. K. Mishra, T. Ye, S. Banday, R. P. Thakare, C. C. T.-T. Su, N. N. H. Pham, A. Ali, A. Kulshreshtha, S. R. Chowdhury, T. M. Simone, K. Hu, L. J. Zhu, B. Eisenhaber, S. K. Deibler, K. Simin, , M. R. Green

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

bioRxiv · Oct 21, 2023 · PreprintCancer Biology

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

bioRxiv · Jun 21, 2022Cancer Biology