Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal clades
W. Joyce, K. He, M. Zhang, S. Ogunsola, X. Wu, K. T. Joseph, D. Bogomolny, W. Yu, M. S. Springer, J. Xie, A. Signore, K. L. Campbell
The paper shows that genetic excision of a cardiac troponin I extension in mammals allows for high heart rates by mimicking phosphorylation without adrenergic stimulation.
bioRxiv · May 19, 2023Evolutionary Biology