Author

M. Saccas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Taffoni· 2 shared H. Chamma· 2 shared I. K. Vila· 2 shared J. Marines· 2 shared J. Vidal-Dupiol· 2 shared N. Laguette· 2 shared A. Bouzid· 1 shared A. Steer· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

C. Taffoni

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Reconstructing the dynamics of past coral endosymbiotic algae communities using coral ancient DNA (coraDNA)

O. Rey, D. Dissard, E. Toulza, T. Guinebert, M. Saccas, J.-F. Allienne, J. Butscher, M. B. Zoubir, G. Iwankow, C. Tougard, J. Vidal-Dupiol

This study reconstructs past Symbiodiniaceae communities in Porites lobata corals using ancient DNA, revealing stable core microbiota and changes during extreme heat events.

bioRxiv · Mar 21, 2024Evolutionary Biology

Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS)

J. Gawra, A. Valdivieso, F. Roux, M. Laporte, J. de Lorgeril, Y. Gueguen, M. Saccas, J.-M. Escoubas, C. Montagnani, D. Destoumieux-Garzon, F. Lagarde, M. Leroy, P. Haffner, B. Petton, C. Cosseau, , J. Vidal-Dupiol

This study shows that both genetic and epigenetic variations contribute to rapid adaptation of oyster populations to POMS, with epigenetic factors explaining a significant portion of phenotypic variation.

bioRxiv · Mar 9, 2023Evolutionary Biology

The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

C. Taffoni, J. Marines, H. Chamma, M. Saccas, A. Bouzid, S. Guha, A.-L. Chaves Valadao, K. Polak, M. Del Rio, C. Gongora, D. Pineau, J.-P. Hugnot, K. Kissa, L. Fontenille, F. P. Blanchet, , N. Laguette

This study shows DNA-PK and cGAS work together to drive inflammation in tumors, affecting immunogenicity and patient outcomes.

bioRxiv · Jun 8, 2022 · PreprintCancer Biology

Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses

I. K. Vila, H. Chamma, A. Steer, C. Taffoni, L. S. Reinert, E. Turtoi, M. Saccas, J. Marines, L. Jin, X. Bonnefont, S. R. Paludan, D. Vlachakis, A. Turtoi, N. Laguette

This study identifies Sting as a regulator of fatty acid metabolism and shows its cross-talk with PUFAs to modulate inflammatory responses.

bioRxiv · Dec 22, 2020Immunology