M. Laporte

Alstrom syndrome proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop in Drosophila

This study identifies Alms1a and Alms1b as regulators of centriole duplication in Drosophila by enabling the Plk4-Ana2 amplification loop and Sas-6 recruitment.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS)

This study shows that both genetic and epigenetic variations contribute to rapid adaptation of oyster populations to POMS, with epigenetic factors explaining a significant portion of phenotypic variation.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Epigenetic and genetic differentiation between Coregonus species pairs

The paper examines genetic and epigenetic differentiation between sympatric benthic-limnetic whitefish species pairs, finding evidence that DNA methylation contributes to mutagenesis and genetic divergence during speciation.

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile

A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity

This study shows that a longer interval between SARS-CoV-2 mRNA vaccine doses enhances B cell responses but has minimal impact on T cell immunity.

Environmental selection, rather than neutral processes, best explain patterns of diversity in a tropical rainforest fish

The paper investigates factors driving biodiversity in a tropical rainforest fish, finding environmental selection, not neutral processes, explains genetic and morphological variation.

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

Effect of SARS-CoV-2 spike mutations on its activation by TMPRSS2 and TMPRSS13

This study investigates how mutations in the SARS-CoV-2 spike protein's S2 motif affect activation by TMPRSS2 and TMPRSS13 proteases, finding that K814 is dispensable for TMPRSS2 but not TMPRSS13.

Genome assembly, structural variants, and genetic differentiation between Lake Whitefish young species pairs (Coregonus sp.) with long and short reads

The paper assembles genomes and identifies structural variants in two Lake Whitefish species pairs using long and short reads, finding that SVs cover more genome than SNPs and are linked to transposable elements.

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

The paper examines B and T cell immunity responses to a 16-week interval BNT162b2 vaccine regimen, finding robust immune memory and functional associations between immune components.

SFI1 and centrin form a distal end complex critical for proper centriole architecture and ciliogenesis

This study identifies SFI1 and centrin as a distal end complex essential for centriole architecture and ciliogenesis in human cells.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

The paper discusses the implications of spike-glycoprotein processing by Furin and TMPRSS2 on SARS-CoV-2 infectivity and cell entry, but the manuscript has been withdrawn.

Genome-wide DNA methylation predicts environmentally-driven life history variation in a marine fish

This study shows that DNA methylation patterns differ between two life history strategies in capelin, suggesting epigenetic changes, not genetic differences, drive these variations.

Locally-adaptive inversions modulate genetic variation at different geographic scales in a seaweed fly

This study examines how chromosomal inversions influence genetic variation across geographic scales in the seaweed fly, finding they differentiate populations more strongly than collinear regions.

SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion

This study investigates the roles of Furin and TMPRSS2 in SARS-CoV-2 spike protein processing and viral entry, showing their synergistic effects and suggesting combined inhibitors as antivirals.

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

This paper identifies how SARS-CoV-2 and other coronaviruses' spike proteins are adapted to specific airway temperatures and proteases, enhancing their transmission and pathogenicity.

Anthropogenic disturbance drives dispersal syndromes, demography, and gene flow in spatially structured amphibian populations

This study shows that human-driven habitat patch turnover affects dispersal rates, phenotypic specialization, and genetic structure in amphibian populations.

Transgenerational dispersal plasticity and its fitness consequences are under genetic control

This study investigates how genotype influences transgenerational plasticity of dispersal traits across 200 clonal generations in ciliates, showing stable inheritance and genotype-dependent fitness effects.

The role of genomic vs. epigenomic variation in shaping patterns of convergent transcriptomic variation across continents in a young species complex

The paper quantifies the relative contribution of genomic and epigenomic variation to convergent gene expression differences in four whitefish species pairs across continents.

Evidence for influenza B virus hemagglutinin adaptation to the human host: high cleavability, acid-stability and preference for cool temperature

This study compares influenza B virus (IBV) and influenza A virus (IAV) hemagglutinin (HA) adaptation to human airways, finding IBV HA is more cleavable, acid-stable, and temperature-preferred for human upper airways.

Demography, genetic, and extinction process in a spatially structured population of lekking bird

This study examines demographic and genetic factors in the extinction of a lekking bird population, finding a severe decline and low genetic diversity without evidence of inbreeding depression.

Adaptive and maladaptive genetic diversity in small populations; insights from the Brook Charr (Salvelinus fontinalis) case study

The paper examines genetic diversity in Brook Charr populations, finding increased deleterious mutations in isolated populations and environmental associations with adaptive loci.

Kin-dependent dispersal influences relatedness and genetic structuring in a lek system

The paper examines how kin-dependent dispersal affects relatedness and genetic structure in a lekking bird population, finding stronger spatial relatedness and genetic structuring in males than females.