S. Guha

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer

This study uses LASSO regression and bioinformatics tools to identify prognostic genes in breast cancer, finding six chemokines associated with disease progression.

Crude extract of Ruellia tuberosa L. flower induces intracellular ROS, promotes DNA damage and apoptosis in Triple Negative Breast Cancer Cells

This study shows that the methanolic extract of Ruellia tuberosa L. flower induces ROS, causes G0/G1 cell cycle arrest, and promotes apoptosis in TNBC cells without toxicity in mice.

ERG1A K+ Channel Increases Intracellular Calcium Concentration through Modulation of Calsequestrin1 in C2C12 Myotubes

This study shows that ERG1A overexpression in C2C12 myotubes reduces calsequestrin1 levels, leading to increased intracellular calcium concentration through modulation of calcium buffering.

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

Integration of silicon chip microstructures for in-line microbial cell lysis in soft microfluidics

The paper develops a method to integrate silicon microstructures into soft microfluidic devices for in-line microbial cell lysis using piezoelectric actuation.

Theoretical analysis of cargo transport by catch bonded motors in optical trapping assays

This paper analyzes cargo transport by catch bonded dynein motors using theory and simulations, finding that catch bonding increases persistent motion and can cause non-monotonic first passage times.

The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

This study shows DNA-PK and cGAS work together to drive inflammation in tumors, affecting immunogenicity and patient outcomes.

Multivalent binding proteins can drive collapse and reswelling of chromatin in confinement

This study shows that multivalent binding proteins can cause chromatin to collapse and reswell in confined spaces, with reswelling dependent on protein concentration and confinement strength.

Rational tuning of a membrane-perforating antimicrobial peptide to selectively target membranes of different lipid composition

This paper tunes an antimicrobial peptide to selectively target membranes of different lipid compositions using high-throughput screening and molecular dynamics simulations.