TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
D. Wuenkhaus, R. Tang, K. Nyame, N. N. Laqtom, M. Schweizer, A. S. Rosato, E. K. Kroegsaeter, C. Wollnik, M. Abu-Remaileh, C. Grimm, G. Hermey, R. Kuhn, D. Gruber-Schoffnegger, S. Markmann
This study shows TRPML1 activation reduces lysosomal storage in CLN3-deficient retinal cells but does not restore BMP levels.
bioRxiv · Jun 21, 2023Cell Biology